Nayantara has done the female lead role in the movie E with Jeeva with S.P.Jananathan directing the movie. She has done the role of Jothi in the movie with Jeeva playing the role of Easwaran and is called as E in the movie. Jeeva with Karunaas lives in a slum area and is involved in small thefts and goes to jail now and then. Nayantara comes nearby the area and Jeeva becomes a friend to her for her money.

In a particular situation Jeeva saves a doctor, the role played by Ashish Vidhyarthi from the hands of Pasupathy. But when he comes to that the doctor uses the medicines rejected in the foreign countries and tests them on poor and downtrodden people and is the cause of many deaths in the city, tries to kill him with the help of Pasupathy. Karunaas takes care of the comedy part of the story and Nayantara plays a completing different role and the audiences leave the theatre with a heavy heart with her character in mind. Music for the movie has been composed by Srikanth Deva.